Immunohistochemical expression of aromatase cyp19a1a and cyp19a1b in the ovary and brain of zebrafish (Danio rerio) exposed to different concentrations of bisphenol A

Bisphenol A (BPA) is used to produce plastic and derived products in multitude of daily utensils, being one the industrial compounds most widely used. This endocrine disrupting chemical (EDCs) a well-known environmental pollutant released into aquatic environment from wastewater, sewage sludge or landfill leachate. Aromatases are considered potential targets EDCs with characteristics that make them suitable biomarkers exposure their effects. The main objective our study was evaluate expression cyp19a aromatase as toxicological endpoint after BPA through identification assessment alterations cells responsible for cyp19a1a cyp19a1b zebrafish ovary brain using different concentrations water. Immunohistochemistry analyze these enzymes female exposed not (1, 10, 100 1000 ?g / L) water (n = 6/group) 14 days. results obtained this showed system, involved synthesis steroid compounds, specially located distinct oocyte stages (cyp19a1a) radial glial (cyp19a1b). An overexpression aromatases observed zebrafish, peaking concentration 10 µg/L showing be good identify early effects low concentrations. To knowledge, first localize quantify fish